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《医学前沿（英文）》 2017年 第11卷 第2期 页码 253-265 doi: 10.1007/s11684-017-0508-9
The main constituents of a typical medicinal herb, Polygonum multiflorum (Heshouwu in Chinese), that induces idiosyncratic liver injury remain unclear. Our previous work has shown that cotreatment with a nontoxic dose of lipopolysaccharide (LPS) and therapeutic dose of Heshouwu can induce liver injury in rats, whereas the solo treatment cannot induce observable injury. In the present work, using the constituent “knock-out” and “knock-in” strategy, we found that the ethyl acetate (EA) extract of Heshouwu displayed comparable idiosyncratic hepatotoxicity to the whole extract in LPS-treated rats. Results indicated a significant elevation of plasma alanine aminotransferase, aspartate aminotransferase, and liver histologic changes, whereas other separated fractions failed to induce liver injury. The mixture of EA extract with other separated fractions induced comparable idiosyncratic hepatotoxicity to the whole extract in LPS-treated rats. Chemical analysis further revealed that 2,3,5,4'-tetrahydroxy trans-stilbene-2-O-β-glucoside (trans-SG) and its cis-isomer were the two major compounds in EA extract. Furthermore, the isolated cis-, and not its trans-isomer, displayed comparable idiosyncratic hepatotoxicity to EA extract in LPS-treated rats. Higher contents of cis-SG were detected in Heshouwu liquor or preparations from actual liver intoxication patients associated with Heshouwu compared with general collected samples. In addition, plasma metabolomics analysis showed that cis-SG-disturbing enriched pathways remarkably differed from trans-SG ones in LPS-treated rats. All these results suggested that cis-SG was closely associated with the idiosyncratic hepatotoxicity of Heshouwu. Considering that the cis-trans isomerization of trans-SG was mediated by ultraviolet light or sunlight, our findings serve as reference for controlling photoisomerization in drug discovery and for the clinical use of Heshouwu and stilbene-related medications.
关键词： Polygonum multiflorum idiosyncratic hepatotoxicity metabolomics stilbene cis-transisomerization
具有客体适应型孔道的阴离子柱撑超微孔材料实现顺-/反-烯烃高效分离
张照强, 崔希利, 姜小明, 丁琦, 崔稷宇, 张袁斌, Youssef Belmabkhout, Karim Adil, Mohamed Eddaoudi, 邢华斌
《工程（英文）》 2022年 第11卷 第4期 页码 82-88 doi: 10.1016/j.eng.2021.10.013
顺-/反-烯烃异构体在石油化工行业具有重要应用价值，然而其极为相似的物理化学性质为节能高效的分离纯化技术的开发带来了巨大的挑战。本文设计的阴离子柱撑超微孔金属-有机框架材料，即ZU-36-Ni和ZU-36-Fe，首次实现了基于分子筛分效应的顺-/反-2-丁烯高效分离。ZU-36-Ni 具有智能的客体适应型孔道结构，其对反-2-丁烯呈现出高吸附容量（2.45 mmol∙g−1）并对顺-2-丁烯高效排阻，可从混合气中分离获得99.99%的高纯度顺-2-丁烯气体。密度泛函理论计算表明：当反-2-丁烯进入孔道时，ZU-36-Ni 的有机配体在主-客体相互作用下可定向旋转，从而导致孔穴扩张并使孔道更加适应反-2-丁烯形状及尺寸，加之ZU-36-Ni 具有可匹配反-2-丁烯三维尺寸的最优孔穴维度，使得反-2-丁烯可以被高效吸附。ZU-36-Ni的适应性行为可最大限度地强化ZU-36-Ni 和反-2-丁烯的主-客体作用，不仅有利于提升反-2-丁烯的优先吸附及动力学扩散行为，同时可实现对顺-2-丁烯的高效分子筛分。本工作为拓展孔穴工程在先进智能或适应型多孔材料在客体分子辨识领域的应用提供了新思路。
关键词： 吸附分离 顺-/反-丁烯 超微孔金属-有机框架材料 孔工程 客体适应性行为
标题 作者 时间 类型 操作
Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum
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